A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site

Spliceosomal U6 snRNA is modified by m6A. Here the authors show that m6A modification on U6 snRNA promotes efficient recognition of the splice site through cooperating with U5 snRNA, indicating that U6 snRNA m6A allows the 5’ exon sequence variation.

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Autores principales: Yuma Ishigami, Takayuki Ohira, Yui Isokawa, Yutaka Suzuki, Tsutomu Suzuki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/98277225bb5c42e7b6e2286282d43c55
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