A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site

Spliceosomal U6 snRNA is modified by m6A. Here the authors show that m6A modification on U6 snRNA promotes efficient recognition of the splice site through cooperating with U5 snRNA, indicating that U6 snRNA m6A allows the 5’ exon sequence variation.

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Autores principales:	Yuma Ishigami, Takayuki Ohira, Yui Isokawa, Yutaka Suzuki, Tsutomu Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98277225bb5c42e7b6e2286282d43c55
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spelling	oai:doaj.org-article:98277225bb5c42e7b6e2286282d43c552021-12-02T14:49:22ZA single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site10.1038/s41467-021-23457-62041-1723https://doaj.org/article/98277225bb5c42e7b6e2286282d43c552021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23457-6https://doaj.org/toc/2041-1723Spliceosomal U6 snRNA is modified by m6A. Here the authors show that m6A modification on U6 snRNA promotes efficient recognition of the splice site through cooperating with U5 snRNA, indicating that U6 snRNA m6A allows the 5’ exon sequence variation.Yuma IshigamiTakayuki OhiraYui IsokawaYutaka SuzukiTsutomu SuzukiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuma Ishigami Takayuki Ohira Yui Isokawa Yutaka Suzuki Tsutomu Suzuki A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
description	Spliceosomal U6 snRNA is modified by m6A. Here the authors show that m6A modification on U6 snRNA promotes efficient recognition of the splice site through cooperating with U5 snRNA, indicating that U6 snRNA m6A allows the 5’ exon sequence variation.
format	article
author	Yuma Ishigami Takayuki Ohira Yui Isokawa Yutaka Suzuki Tsutomu Suzuki
author_facet	Yuma Ishigami Takayuki Ohira Yui Isokawa Yutaka Suzuki Tsutomu Suzuki
author_sort	Yuma Ishigami
title	A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
title_short	A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
title_full	A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
title_fullStr	A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
title_full_unstemmed	A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
title_sort	single m6a modification in u6 snrna diversifies exon sequence at the 5’ splice site
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98277225bb5c42e7b6e2286282d43c55
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A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site

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