Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

Maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement of the STAT1 transcription factor. However, the contribution of tonic levels of IFN to i...

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Autores principales: Isabelle J Marié, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele V Baracho, Azlann Arnett, Haiyan S Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S Watowich, Bernard Khor, David E Levy
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
interferon
inflammation
homeostasis
Th17
hematopoietic stem cells
microbiome
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/982a4035ae764dbdbb7abc2f4d9fe2a7
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https://doaj.org/article/982a4035ae764dbdbb7abc2f4d9fe2a7

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