Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

Maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement of the STAT1 transcription factor. However, the contribution of tonic levels of IFN to i...

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Bibliographic Details
Main Authors: Isabelle J Marié, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele V Baracho, Azlann Arnett, Haiyan S Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S Watowich, Bernard Khor, David E Levy
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
interferon
inflammation
homeostasis
Th17
hematopoietic stem cells
microbiome
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/982a4035ae764dbdbb7abc2f4d9fe2a7
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