Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

ABSTRACT Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in the Old World and a highly fatal hantavirus cardiopulmonary syndrome (HCPS) in the New World. No vaccines or antiviral therapies are currently available to prevent or treat hantavirus disease, and gaps in our understanding o...

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Auteurs principaux: Lara M. Kleinfelter, Rohit K. Jangra, Lucas T. Jae, Andrew S. Herbert, Eva Mittler, Katie M. Stiles, Ariel S. Wirchnianski, Margaret Kielian, Thijn R. Brummelkamp, John M. Dye, Kartik Chandran
Format: article
Langue:EN
Publié: American Society for Microbiology 2015
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Accès en ligne:https://doaj.org/article/983bfed9990349deb89d2c2be0fb9944
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