Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

The timing of cell fate choices is usually unknown, because we have to rely on indirect evidence of their molecular basis. Here, the authors introduce a method to infer decision times from marker onset in cell genealogies, and find evidence refuting the paradigmatic PU.1/GATA1 cell fate switch.

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Autores principales: Michael K. Strasser, Philipp S. Hoppe, Dirk Loeffler, Konstantinos D. Kokkaliaris, Timm Schroeder, Fabian J. Theis, Carsten Marr
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/983bff561cd148d39c9c6755fd3f3b03
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