Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

The timing of cell fate choices is usually unknown, because we have to rely on indirect evidence of their molecular basis. Here, the authors introduce a method to infer decision times from marker onset in cell genealogies, and find evidence refuting the paradigmatic PU.1/GATA1 cell fate switch.

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Autores principales:	Michael K. Strasser, Philipp S. Hoppe, Dirk Loeffler, Konstantinos D. Kokkaliaris, Timm Schroeder, Fabian J. Theis, Carsten Marr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/983bff561cd148d39c9c6755fd3f3b03
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spelling	oai:doaj.org-article:983bff561cd148d39c9c6755fd3f3b032021-12-02T16:50:08ZLineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm10.1038/s41467-018-05037-32041-1723https://doaj.org/article/983bff561cd148d39c9c6755fd3f3b032018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05037-3https://doaj.org/toc/2041-1723The timing of cell fate choices is usually unknown, because we have to rely on indirect evidence of their molecular basis. Here, the authors introduce a method to infer decision times from marker onset in cell genealogies, and find evidence refuting the paradigmatic PU.1/GATA1 cell fate switch.Michael K. StrasserPhilipp S. HoppeDirk LoefflerKonstantinos D. KokkaliarisTimm SchroederFabian J. TheisCarsten MarrNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael K. Strasser Philipp S. Hoppe Dirk Loeffler Konstantinos D. Kokkaliaris Timm Schroeder Fabian J. Theis Carsten Marr Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
description	The timing of cell fate choices is usually unknown, because we have to rely on indirect evidence of their molecular basis. Here, the authors introduce a method to infer decision times from marker onset in cell genealogies, and find evidence refuting the paradigmatic PU.1/GATA1 cell fate switch.
format	article
author	Michael K. Strasser Philipp S. Hoppe Dirk Loeffler Konstantinos D. Kokkaliaris Timm Schroeder Fabian J. Theis Carsten Marr
author_facet	Michael K. Strasser Philipp S. Hoppe Dirk Loeffler Konstantinos D. Kokkaliaris Timm Schroeder Fabian J. Theis Carsten Marr
author_sort	Michael K. Strasser
title	Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
title_short	Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
title_full	Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
title_fullStr	Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
title_full_unstemmed	Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
title_sort	lineage marker synchrony in hematopoietic genealogies refutes the pu.1/gata1 toggle switch paradigm
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/983bff561cd148d39c9c6755fd3f3b03
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Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

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