Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection factors EXO1 and BLM-DNA2.

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Bibliographic Details
Main Authors: James M. Daley, Nozomi Tomimatsu, Grace Hooks, Weibin Wang, Adam S. Miller, Xiaoyu Xue, Kevin A. Nguyen, Hardeep Kaur, Elizabeth Williamson, Bipasha Mukherjee, Robert Hromas, Sandeep Burma, Patrick Sung
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/984479d037a94bbc940c8e7db07e22e0
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Summary:DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection factors EXO1 and BLM-DNA2.

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