Characterization, biological evaluation and molecular docking of mulberry fruit pectin
Abstract Contemplating the exemplary benefits of pectin on human health, we precisely characterized and evaluated the antibacterial and anticancer activities from purified Mulberry Fruit Pectins (MFP). Here, we tested BR-2 and S-13 varieties of mulberry fruit pectins against six bacterial strains an...
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Nature Portfolio
2020
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oai:doaj.org-article:984a4d2ea4934914a4ab36436f30fed32021-12-02T11:43:44ZCharacterization, biological evaluation and molecular docking of mulberry fruit pectin10.1038/s41598-020-78086-82045-2322https://doaj.org/article/984a4d2ea4934914a4ab36436f30fed32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78086-8https://doaj.org/toc/2045-2322Abstract Contemplating the exemplary benefits of pectin on human health, we precisely characterized and evaluated the antibacterial and anticancer activities from purified Mulberry Fruit Pectins (MFP). Here, we tested BR-2 and S-13 varieties of mulberry fruit pectins against six bacterial strains and two human cancer cell lines (HT-29 and Hep G-2), using MIC and an in vitro cell-based assay respectively. The BR-2 mulberry fruit pectin performs superior to S-13 by inhibiting strong bacterial growth (MIC = 500–1000 μg/mL) against tested bacterial strains and cytotoxic activities at the lowest concentration (10 µg/ml) against the Hep G-2 cell line. However, both tested drugs failed to exhibit cytotoxicity on the human colon cancer cell line (HT-29). Based on molecular interaction through docking, pectin binds effectively with the receptors (1e3g, 3t0c, 5czz, 6j7l, 6v40, 5ibs, 5zsy, and 6ggb) and proven to be a promising antimicrobial and anti-cancer agents. The pursuit of unexploited drugs from mulberry fruit pectin will potentially combat against bacterial and cancer diseases. Finally, future perspectives of MFP for the treatment of many chronic diseases will help immensely due to their therapeutic properties.R. Venkatesh KumarDevika SrivastavaVandana SinghUmesh KumarVijay Kumar VishvakarmaPrashant SinghDinesh KumarRajesh KumarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-16 (2020) |
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Medicine R Science Q R. Venkatesh Kumar Devika Srivastava Vandana Singh Umesh Kumar Vijay Kumar Vishvakarma Prashant Singh Dinesh Kumar Rajesh Kumar Characterization, biological evaluation and molecular docking of mulberry fruit pectin |
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Abstract Contemplating the exemplary benefits of pectin on human health, we precisely characterized and evaluated the antibacterial and anticancer activities from purified Mulberry Fruit Pectins (MFP). Here, we tested BR-2 and S-13 varieties of mulberry fruit pectins against six bacterial strains and two human cancer cell lines (HT-29 and Hep G-2), using MIC and an in vitro cell-based assay respectively. The BR-2 mulberry fruit pectin performs superior to S-13 by inhibiting strong bacterial growth (MIC = 500–1000 μg/mL) against tested bacterial strains and cytotoxic activities at the lowest concentration (10 µg/ml) against the Hep G-2 cell line. However, both tested drugs failed to exhibit cytotoxicity on the human colon cancer cell line (HT-29). Based on molecular interaction through docking, pectin binds effectively with the receptors (1e3g, 3t0c, 5czz, 6j7l, 6v40, 5ibs, 5zsy, and 6ggb) and proven to be a promising antimicrobial and anti-cancer agents. The pursuit of unexploited drugs from mulberry fruit pectin will potentially combat against bacterial and cancer diseases. Finally, future perspectives of MFP for the treatment of many chronic diseases will help immensely due to their therapeutic properties. |
format |
article |
author |
R. Venkatesh Kumar Devika Srivastava Vandana Singh Umesh Kumar Vijay Kumar Vishvakarma Prashant Singh Dinesh Kumar Rajesh Kumar |
author_facet |
R. Venkatesh Kumar Devika Srivastava Vandana Singh Umesh Kumar Vijay Kumar Vishvakarma Prashant Singh Dinesh Kumar Rajesh Kumar |
author_sort |
R. Venkatesh Kumar |
title |
Characterization, biological evaluation and molecular docking of mulberry fruit pectin |
title_short |
Characterization, biological evaluation and molecular docking of mulberry fruit pectin |
title_full |
Characterization, biological evaluation and molecular docking of mulberry fruit pectin |
title_fullStr |
Characterization, biological evaluation and molecular docking of mulberry fruit pectin |
title_full_unstemmed |
Characterization, biological evaluation and molecular docking of mulberry fruit pectin |
title_sort |
characterization, biological evaluation and molecular docking of mulberry fruit pectin |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/984a4d2ea4934914a4ab36436f30fed3 |
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