The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers...

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Auteurs principaux: Jennifer Ma, Jeremy Setton, Nancy Y. Lee, Nadeem Riaz, Simon N. Powell
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/989e83e9fb614cad8639f2b928fc7330
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