The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers...
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Nature Portfolio
2018
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oai:doaj.org-article:989e83e9fb614cad8639f2b928fc73302021-12-02T15:33:57ZThe therapeutic significance of mutational signatures from DNA repair deficiency in cancer10.1038/s41467-018-05228-y2041-1723https://doaj.org/article/989e83e9fb614cad8639f2b928fc73302018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05228-yhttps://doaj.org/toc/2041-1723Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers.Jennifer MaJeremy SettonNancy Y. LeeNadeem RiazSimon N. PowellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Jennifer Ma Jeremy Setton Nancy Y. Lee Nadeem Riaz Simon N. Powell The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
description |
Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers. |
format |
article |
author |
Jennifer Ma Jeremy Setton Nancy Y. Lee Nadeem Riaz Simon N. Powell |
author_facet |
Jennifer Ma Jeremy Setton Nancy Y. Lee Nadeem Riaz Simon N. Powell |
author_sort |
Jennifer Ma |
title |
The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
title_short |
The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
title_full |
The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
title_fullStr |
The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
title_full_unstemmed |
The therapeutic significance of mutational signatures from DNA repair deficiency in cancer |
title_sort |
therapeutic significance of mutational signatures from dna repair deficiency in cancer |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/989e83e9fb614cad8639f2b928fc7330 |
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