The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers...

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Main Authors:	Jennifer Ma, Jeremy Setton, Nancy Y. Lee, Nadeem Riaz, Simon N. Powell
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/989e83e9fb614cad8639f2b928fc7330
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spelling	oai:doaj.org-article:989e83e9fb614cad8639f2b928fc73302021-12-02T15:33:57ZThe therapeutic significance of mutational signatures from DNA repair deficiency in cancer10.1038/s41467-018-05228-y2041-1723https://doaj.org/article/989e83e9fb614cad8639f2b928fc73302018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05228-yhttps://doaj.org/toc/2041-1723Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers.Jennifer MaJeremy SettonNancy Y. LeeNadeem RiazSimon N. PowellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer Ma Jeremy Setton Nancy Y. Lee Nadeem Riaz Simon N. Powell The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
description	Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers.
format	article
author	Jennifer Ma Jeremy Setton Nancy Y. Lee Nadeem Riaz Simon N. Powell
author_facet	Jennifer Ma Jeremy Setton Nancy Y. Lee Nadeem Riaz Simon N. Powell
author_sort	Jennifer Ma
title	The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
title_short	The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
title_full	The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
title_fullStr	The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
title_full_unstemmed	The therapeutic significance of mutational signatures from DNA repair deficiency in cancer
title_sort	therapeutic significance of mutational signatures from dna repair deficiency in cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/989e83e9fb614cad8639f2b928fc7330
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The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

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