Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp

Abstract P-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among the active compounds, two of them significantly increased intracell...

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Autores principales: Jerónimo Laiolo, Priscila Ailin Lanza, Oscar Parravicini, Cecilia Barbieri, Daniel Insuasty, Justo Cobo, D. Mariano Adolfo Vera, Ricardo Daniel Enriz, Maria Cecilia Carpinella
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/98b225c1e09c43bfa1d0517e683523c4
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