Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes

Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes

Abstract The endothelial glycocalyx (eGC) is considered a key regulator of several mechanisms that prevent vascular injury and disease. Degradation of this macromolecular layer may be associated with post-transplant graft dysfunction. In this study, we aimed to demonstrate the benefits of eGC protec...

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Bibliographic Details
Main Authors: Kentaro Noda, Brian J. Philips, Mark E. Snyder, Julie A. Phillippi, Mara Sullivan, Donna B. Stolz, Xi Ren, James D. Luketich, Pablo G. Sanchez
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/98cf30a0f9ce40b5b2955bce29674e74
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https://doaj.org/article/98cf30a0f9ce40b5b2955bce29674e74

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