Simultaneous Coinfection of Macaques with Zika and Dengue Viruses Does not Enhance Acute Plasma Viremia but Leads to Activation of Monocyte Subsets and Biphasic Release of Pro-inflammatory Cytokines

Simultaneous Coinfection of Macaques with Zika and Dengue Viruses Does not Enhance Acute Plasma Viremia but Leads to Activation of Monocyte Subsets and Biphasic Release of Pro-inflammatory Cytokines

Abstract The consequences of simultaneous infection with Zika (ZIKV) and Dengue (DENV) viruses are poorly understood. Here we show that rhesus macaques experimentally coinfected simultaneously with ZIKV and DENV-2 demonstrated ZIKV or DENV replication without an enhancement of either infection. Coin...

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Bibliographic Details
Main Authors: William G. Valiant, Mary J. Mattapallil, Stephen Higgs, Yan-Jang S. Huang, Dana L. Vanlandingham, Mark G. Lewis, Joseph J. Mattapallil
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/98da3e2a93a84a69b1d1d0c93ea35080
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