Identification of KasA as the cellular target of an anti-tubercular scaffold
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inhibitors of fatty acid biosynthesis in bacteria.
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2016
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oai:doaj.org-article:98e2a1212a5248b996b2c2ff78fce60e2021-12-02T15:34:32ZIdentification of KasA as the cellular target of an anti-tubercular scaffold10.1038/ncomms125812041-1723https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12581https://doaj.org/toc/2041-1723Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inhibitors of fatty acid biosynthesis in bacteria.Katherine A. AbrahamsChun-wa ChungSonja Ghidelli-DisseJoaquín RullasMaría José Rebollo-LópezSudagar S. GurchaJonathan A. G. CoxAlfonso MendozaElena Jiménez-NavarroMaría Santos Martínez-MartínezMargarete NeuAnthony ShillingsPaul HomesArgyrides ArgyrouRuth CasanuevaNicholas J. LomanPatrick J. MoynihanJoël LelièvreCarolyn SelenskiMatthew AxtmanLaurent KremerMarcus BantscheffIñigo Angulo-BarturenMónica Cacho IzquierdoNicholas C. CammackGerard DrewesLluis BallellDavid BarrosGurdyal S. BesraRobert H. BatesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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EN |
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Science Q |
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Science Q Katherine A. Abrahams Chun-wa Chung Sonja Ghidelli-Disse Joaquín Rullas María José Rebollo-López Sudagar S. Gurcha Jonathan A. G. Cox Alfonso Mendoza Elena Jiménez-Navarro María Santos Martínez-Martínez Margarete Neu Anthony Shillings Paul Homes Argyrides Argyrou Ruth Casanueva Nicholas J. Loman Patrick J. Moynihan Joël Lelièvre Carolyn Selenski Matthew Axtman Laurent Kremer Marcus Bantscheff Iñigo Angulo-Barturen Mónica Cacho Izquierdo Nicholas C. Cammack Gerard Drewes Lluis Ballell David Barros Gurdyal S. Besra Robert H. Bates Identification of KasA as the cellular target of an anti-tubercular scaffold |
| description |
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inhibitors of fatty acid biosynthesis in bacteria. |
| format |
article |
| author |
Katherine A. Abrahams Chun-wa Chung Sonja Ghidelli-Disse Joaquín Rullas María José Rebollo-López Sudagar S. Gurcha Jonathan A. G. Cox Alfonso Mendoza Elena Jiménez-Navarro María Santos Martínez-Martínez Margarete Neu Anthony Shillings Paul Homes Argyrides Argyrou Ruth Casanueva Nicholas J. Loman Patrick J. Moynihan Joël Lelièvre Carolyn Selenski Matthew Axtman Laurent Kremer Marcus Bantscheff Iñigo Angulo-Barturen Mónica Cacho Izquierdo Nicholas C. Cammack Gerard Drewes Lluis Ballell David Barros Gurdyal S. Besra Robert H. Bates |
| author_facet |
Katherine A. Abrahams Chun-wa Chung Sonja Ghidelli-Disse Joaquín Rullas María José Rebollo-López Sudagar S. Gurcha Jonathan A. G. Cox Alfonso Mendoza Elena Jiménez-Navarro María Santos Martínez-Martínez Margarete Neu Anthony Shillings Paul Homes Argyrides Argyrou Ruth Casanueva Nicholas J. Loman Patrick J. Moynihan Joël Lelièvre Carolyn Selenski Matthew Axtman Laurent Kremer Marcus Bantscheff Iñigo Angulo-Barturen Mónica Cacho Izquierdo Nicholas C. Cammack Gerard Drewes Lluis Ballell David Barros Gurdyal S. Besra Robert H. Bates |
| author_sort |
Katherine A. Abrahams |
| title |
Identification of KasA as the cellular target of an anti-tubercular scaffold |
| title_short |
Identification of KasA as the cellular target of an anti-tubercular scaffold |
| title_full |
Identification of KasA as the cellular target of an anti-tubercular scaffold |
| title_fullStr |
Identification of KasA as the cellular target of an anti-tubercular scaffold |
| title_full_unstemmed |
Identification of KasA as the cellular target of an anti-tubercular scaffold |
| title_sort |
identification of kasa as the cellular target of an anti-tubercular scaffold |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e |
| work_keys_str_mv |
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