Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues.

Human PDHA2 is a testis-specific gene that codes for the E(1)α subunit of Pyruvate Dehydrogenase Complex (PDC), a crucial enzyme system in cell energy metabolism. Since activation of the PDHA2 gene in somatic cells could be a new therapeutic approach for PDC deficiency, we aimed to identify the regu...

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Autores principales: Ana Pinheiro, Maria João Nunes, Inês Milagre, Elsa Rodrigues, Maria João Silva, Isabel Tavares de Almeida, Isabel Rivera
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/98f103d96456418c925534400a21098f
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