Ultrahigh specificity in a network of computationally designed protein-interaction pairs

The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and complex interaction network.

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Detalles Bibliográficos
Autores principales: Ravit Netzer, Dina Listov, Rosalie Lipsh, Orly Dym, Shira Albeck, Orli Knop, Colin Kleanthous, Sarel J. Fleishman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9939e24b02bd4d13a295f4878802d25a
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