Ultrahigh specificity in a network of computationally designed protein-interaction pairs

The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and complex interaction network.

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Detalles Bibliográficos
Autores principales:	Ravit Netzer, Dina Listov, Rosalie Lipsh, Orly Dym, Shira Albeck, Orli Knop, Colin Kleanthous, Sarel J. Fleishman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9939e24b02bd4d13a295f4878802d25a
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spelling	oai:doaj.org-article:9939e24b02bd4d13a295f4878802d25a2021-12-02T16:49:56ZUltrahigh specificity in a network of computationally designed protein-interaction pairs10.1038/s41467-018-07722-92041-1723https://doaj.org/article/9939e24b02bd4d13a295f4878802d25a2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07722-9https://doaj.org/toc/2041-1723The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and complex interaction network.Ravit NetzerDina ListovRosalie LipshOrly DymShira AlbeckOrli KnopColin KleanthousSarel J. FleishmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ravit Netzer Dina Listov Rosalie Lipsh Orly Dym Shira Albeck Orli Knop Colin Kleanthous Sarel J. Fleishman Ultrahigh specificity in a network of computationally designed protein-interaction pairs
description	The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and complex interaction network.
format	article
author	Ravit Netzer Dina Listov Rosalie Lipsh Orly Dym Shira Albeck Orli Knop Colin Kleanthous Sarel J. Fleishman
author_facet	Ravit Netzer Dina Listov Rosalie Lipsh Orly Dym Shira Albeck Orli Knop Colin Kleanthous Sarel J. Fleishman
author_sort	Ravit Netzer
title	Ultrahigh specificity in a network of computationally designed protein-interaction pairs
title_short	Ultrahigh specificity in a network of computationally designed protein-interaction pairs
title_full	Ultrahigh specificity in a network of computationally designed protein-interaction pairs
title_fullStr	Ultrahigh specificity in a network of computationally designed protein-interaction pairs
title_full_unstemmed	Ultrahigh specificity in a network of computationally designed protein-interaction pairs
title_sort	ultrahigh specificity in a network of computationally designed protein-interaction pairs
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9939e24b02bd4d13a295f4878802d25a
work_keys_str_mv	AT ravitnetzer ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT dinalistov ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT rosalielipsh ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT orlydym ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT shiraalbeck ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT orliknop ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT colinkleanthous ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs AT sareljfleishman ultrahighspecificityinanetworkofcomputationallydesignedproteininteractionpairs
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Ultrahigh specificity in a network of computationally designed protein-interaction pairs

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