Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce <i>CD14</i>, <i>TLR4</i>, and <i>MMP9</i> Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for Atherosclerosis

Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce <i>CD14</i>, <i>TLR4</i>, and <i>MMP9</i> Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for Atherosclerosis

Monocyte-to-macrophage differentiation results in the secretion of various inflammatory mediators and oxidative stress molecules necessary for atherosclerosis pathogenesis. Consequently, this differentiation represents a potential clinical target in atherosclerosis. Calcium dobesilate (CaD), an esta...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Florence Njau, Hermann Haller
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
atherosclerosis
calcium dobesilate
inflammation
monocyte-macrophage differentiation
oxidative stress
PKCδ
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/99557863ac5f4254ae7b9ed9f20f5502
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/99557863ac5f4254ae7b9ed9f20f5502

Ejemplares similares