Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce <i>CD14</i>, <i>TLR4</i>, and <i>MMP9</i> Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for Atherosclerosis
Monocyte-to-macrophage differentiation results in the secretion of various inflammatory mediators and oxidative stress molecules necessary for atherosclerosis pathogenesis. Consequently, this differentiation represents a potential clinical target in atherosclerosis. Calcium dobesilate (CaD), an esta...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/99557863ac5f4254ae7b9ed9f20f5502 |
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