Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

Ageing phenotypes are of great interest but are difficult to study genetically, partly due to the sample sizes required. Here, the authors present a multivariate framework to combine GWAS summary statistics and increase statistical power, identifying additional loci enriched for aging.

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Autores principales:	Paul R. H. J. Timmers, James F. Wilson, Peter K. Joshi, Joris Deelen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9965e11c40b1450baa676536e95faa0a
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spelling	oai:doaj.org-article:9965e11c40b1450baa676536e95faa0a2021-12-02T18:31:30ZMultivariate genomic scan implicates novel loci and haem metabolism in human ageing10.1038/s41467-020-17312-32041-1723https://doaj.org/article/9965e11c40b1450baa676536e95faa0a2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17312-3https://doaj.org/toc/2041-1723Ageing phenotypes are of great interest but are difficult to study genetically, partly due to the sample sizes required. Here, the authors present a multivariate framework to combine GWAS summary statistics and increase statistical power, identifying additional loci enriched for aging.Paul R. H. J. TimmersJames F. WilsonPeter K. JoshiJoris DeelenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul R. H. J. Timmers James F. Wilson Peter K. Joshi Joris Deelen Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
description	Ageing phenotypes are of great interest but are difficult to study genetically, partly due to the sample sizes required. Here, the authors present a multivariate framework to combine GWAS summary statistics and increase statistical power, identifying additional loci enriched for aging.
format	article
author	Paul R. H. J. Timmers James F. Wilson Peter K. Joshi Joris Deelen
author_facet	Paul R. H. J. Timmers James F. Wilson Peter K. Joshi Joris Deelen
author_sort	Paul R. H. J. Timmers
title	Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
title_short	Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
title_full	Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
title_fullStr	Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
title_full_unstemmed	Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
title_sort	multivariate genomic scan implicates novel loci and haem metabolism in human ageing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9965e11c40b1450baa676536e95faa0a
work_keys_str_mv	AT paulrhjtimmers multivariategenomicscanimplicatesnovellociandhaemmetabolisminhumanageing AT jamesfwilson multivariategenomicscanimplicatesnovellociandhaemmetabolisminhumanageing AT peterkjoshi multivariategenomicscanimplicatesnovellociandhaemmetabolisminhumanageing AT jorisdeelen multivariategenomicscanimplicatesnovellociandhaemmetabolisminhumanageing
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Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

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