The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

Sensing of nutrient status coordinates the regulation of liver glucose and lipid metabolism, and is important for metabolic homeostasis. Here the authors report that transcriptional the corepressor CtBP2 can sense nutrient status and coordinate repression of liver glucose and lipid metabolism via Fo...

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Autores principales:	Motohiro Sekiya, Kenta Kainoh, Takehito Sugasawa, Ryunosuke Yoshino, Takatsugu Hirokawa, Hiroaki Tokiwa, Shogo Nakano, Satoru Nagatoishi, Kouhei Tsumoto, Yoshinori Takeuchi, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/996f1a434a0445a0ba8691377b30fab1
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spelling	oai:doaj.org-article:996f1a434a0445a0ba8691377b30fab12021-11-08T11:05:30ZThe transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis10.1038/s41467-021-26638-52041-1723https://doaj.org/article/996f1a434a0445a0ba8691377b30fab12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26638-5https://doaj.org/toc/2041-1723Sensing of nutrient status coordinates the regulation of liver glucose and lipid metabolism, and is important for metabolic homeostasis. Here the authors report that transcriptional the corepressor CtBP2 can sense nutrient status and coordinate repression of liver glucose and lipid metabolism via Fox01 and SREBP1, respectively.Motohiro SekiyaKenta KainohTakehito SugasawaRyunosuke YoshinoTakatsugu HirokawaHiroaki TokiwaShogo NakanoSatoru NagatoishiKouhei TsumotoYoshinori TakeuchiTakafumi MiyamotoTakashi MatsuzakaHitoshi ShimanoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Motohiro Sekiya Kenta Kainoh Takehito Sugasawa Ryunosuke Yoshino Takatsugu Hirokawa Hiroaki Tokiwa Shogo Nakano Satoru Nagatoishi Kouhei Tsumoto Yoshinori Takeuchi Takafumi Miyamoto Takashi Matsuzaka Hitoshi Shimano The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
description	Sensing of nutrient status coordinates the regulation of liver glucose and lipid metabolism, and is important for metabolic homeostasis. Here the authors report that transcriptional the corepressor CtBP2 can sense nutrient status and coordinate repression of liver glucose and lipid metabolism via Fox01 and SREBP1, respectively.
format	article
author	Motohiro Sekiya Kenta Kainoh Takehito Sugasawa Ryunosuke Yoshino Takatsugu Hirokawa Hiroaki Tokiwa Shogo Nakano Satoru Nagatoishi Kouhei Tsumoto Yoshinori Takeuchi Takafumi Miyamoto Takashi Matsuzaka Hitoshi Shimano
author_facet	Motohiro Sekiya Kenta Kainoh Takehito Sugasawa Ryunosuke Yoshino Takatsugu Hirokawa Hiroaki Tokiwa Shogo Nakano Satoru Nagatoishi Kouhei Tsumoto Yoshinori Takeuchi Takafumi Miyamoto Takashi Matsuzaka Hitoshi Shimano
author_sort	Motohiro Sekiya
title	The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
title_short	The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
title_full	The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
title_fullStr	The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
title_full_unstemmed	The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
title_sort	transcriptional corepressor ctbp2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/996f1a434a0445a0ba8691377b30fab1
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The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

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