The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

RPSAP52 is an antisense-transcribed pseudogene of HMGA2 that positively regulates HMGA2 expression. Here, the authors show that reexpression of RPSAP52 promotes tumorigenicity by facilitating IGF2BP2 binding to its mRNA targets and consequently regulates the balance of LIN28B and let-7 levels.

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Autores principales: Cristina Oliveira-Mateos, Anaís Sánchez-Castillo, Marta Soler, Aida Obiols-Guardia, David Piñeyro, Raquel Boque-Sastre, Maria E. Calleja-Cervantes, Manuel Castro de Moura, Anna Martínez-Cardús, Teresa Rubio, Joffrey Pelletier, Maria Martínez-Iniesta, David Herrero-Martín, Oscar M. Tirado, Antonio Gentilella, Alberto Villanueva, Manel Esteller, Lourdes Farré, Sonia Guil
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/997060ff259e4adbb35655aa6d12600d
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https://doaj.org/article/997060ff259e4adbb35655aa6d12600d

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