The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

RPSAP52 is an antisense-transcribed pseudogene of HMGA2 that positively regulates HMGA2 expression. Here, the authors show that reexpression of RPSAP52 promotes tumorigenicity by facilitating IGF2BP2 binding to its mRNA targets and consequently regulates the balance of LIN28B and let-7 levels.

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Autores principales: Cristina Oliveira-Mateos, Anaís Sánchez-Castillo, Marta Soler, Aida Obiols-Guardia, David Piñeyro, Raquel Boque-Sastre, Maria E. Calleja-Cervantes, Manuel Castro de Moura, Anna Martínez-Cardús, Teresa Rubio, Joffrey Pelletier, Maria Martínez-Iniesta, David Herrero-Martín, Oscar M. Tirado, Antonio Gentilella, Alberto Villanueva, Manel Esteller, Lourdes Farré, Sonia Guil
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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spelling oai:doaj.org-article:997060ff259e4adbb35655aa6d12600d2021-12-02T15:36:19ZThe transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition10.1038/s41467-019-11910-62041-1723https://doaj.org/article/997060ff259e4adbb35655aa6d12600d2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11910-6https://doaj.org/toc/2041-1723RPSAP52 is an antisense-transcribed pseudogene of HMGA2 that positively regulates HMGA2 expression. Here, the authors show that reexpression of RPSAP52 promotes tumorigenicity by facilitating IGF2BP2 binding to its mRNA targets and consequently regulates the balance of LIN28B and let-7 levels.Cristina Oliveira-MateosAnaís Sánchez-CastilloMarta SolerAida Obiols-GuardiaDavid PiñeyroRaquel Boque-SastreMaria E. Calleja-CervantesManuel Castro de MouraAnna Martínez-CardúsTeresa RubioJoffrey PelletierMaria Martínez-IniestaDavid Herrero-MartínOscar M. TiradoAntonio GentilellaAlberto VillanuevaManel EstellerLourdes FarréSonia GuilNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cristina Oliveira-Mateos
Anaís Sánchez-Castillo
Marta Soler
Aida Obiols-Guardia
David Piñeyro
Raquel Boque-Sastre
Maria E. Calleja-Cervantes
Manuel Castro de Moura
Anna Martínez-Cardús
Teresa Rubio
Joffrey Pelletier
Maria Martínez-Iniesta
David Herrero-Martín
Oscar M. Tirado
Antonio Gentilella
Alberto Villanueva
Manel Esteller
Lourdes Farré
Sonia Guil
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
description RPSAP52 is an antisense-transcribed pseudogene of HMGA2 that positively regulates HMGA2 expression. Here, the authors show that reexpression of RPSAP52 promotes tumorigenicity by facilitating IGF2BP2 binding to its mRNA targets and consequently regulates the balance of LIN28B and let-7 levels.
format article
author Cristina Oliveira-Mateos
Anaís Sánchez-Castillo
Marta Soler
Aida Obiols-Guardia
David Piñeyro
Raquel Boque-Sastre
Maria E. Calleja-Cervantes
Manuel Castro de Moura
Anna Martínez-Cardús
Teresa Rubio
Joffrey Pelletier
Maria Martínez-Iniesta
David Herrero-Martín
Oscar M. Tirado
Antonio Gentilella
Alberto Villanueva
Manel Esteller
Lourdes Farré
Sonia Guil
author_facet Cristina Oliveira-Mateos
Anaís Sánchez-Castillo
Marta Soler
Aida Obiols-Guardia
David Piñeyro
Raquel Boque-Sastre
Maria E. Calleja-Cervantes
Manuel Castro de Moura
Anna Martínez-Cardús
Teresa Rubio
Joffrey Pelletier
Maria Martínez-Iniesta
David Herrero-Martín
Oscar M. Tirado
Antonio Gentilella
Alberto Villanueva
Manel Esteller
Lourdes Farré
Sonia Guil
author_sort Cristina Oliveira-Mateos
title The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
title_short The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
title_full The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
title_fullStr The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
title_full_unstemmed The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
title_sort transcribed pseudogene rpsap52 enhances the oncofetal hmga2-igf2bp2-ras axis through lin28b-dependent and independent let-7 inhibition
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/997060ff259e4adbb35655aa6d12600d
work_keys_str_mv AT cristinaoliveiramateos thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT anaissanchezcastillo thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT martasoler thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT aidaobiolsguardia thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT davidpineyro thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT raquelboquesastre thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT mariaecallejacervantes thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT manuelcastrodemoura thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT annamartinezcardus thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT teresarubio thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT joffreypelletier thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT mariamartineziniesta thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT davidherreromartin thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT oscarmtirado thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT antoniogentilella thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT albertovillanueva thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT manelesteller thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT lourdesfarre thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT soniaguil thetranscribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT cristinaoliveiramateos transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT anaissanchezcastillo transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT martasoler transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT aidaobiolsguardia transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT davidpineyro transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT raquelboquesastre transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT mariaecallejacervantes transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT manuelcastrodemoura transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT annamartinezcardus transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT teresarubio transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT joffreypelletier transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT mariamartineziniesta transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT davidherreromartin transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT oscarmtirado transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT antoniogentilella transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT albertovillanueva transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT manelesteller transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT lourdesfarre transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
AT soniaguil transcribedpseudogenerpsap52enhancestheoncofetalhmga2igf2bp2rasaxisthroughlin28bdependentandindependentlet7inhibition
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