Targets of complement-fixing antibodies in protective immunity against malaria in children

Targets of complement-fixing antibodies in protective immunity against malaria in children

Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that shou...

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Autores principales: Linda Reiling, Michelle J. Boyle, Michael T. White, Danny W. Wilson, Gaoqian Feng, Rupert Weaver, D. Herbert Opi, Kristina E. M. Persson, Jack S. Richards, Peter M. Siba, Freya J. I. Fowkes, Eizo Takashima, Takafumi Tsuboi, Ivo Mueller, James G. Beeson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/997676a5fefb4ce79727443868c02da7
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spelling oai:doaj.org-article:997676a5fefb4ce79727443868c02da72021-12-02T16:57:21ZTargets of complement-fixing antibodies in protective immunity against malaria in children10.1038/s41467-019-08528-z2041-1723https://doaj.org/article/997676a5fefb4ce79727443868c02da72019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08528-zhttps://doaj.org/toc/2041-1723Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.Linda ReilingMichelle J. BoyleMichael T. WhiteDanny W. WilsonGaoqian FengRupert WeaverD. Herbert OpiKristina E. M. PerssonJack S. RichardsPeter M. SibaFreya J. I. FowkesEizo TakashimaTakafumi TsuboiIvo MuellerJames G. BeesonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Linda Reiling
Michelle J. Boyle
Michael T. White
Danny W. Wilson
Gaoqian Feng
Rupert Weaver
D. Herbert Opi
Kristina E. M. Persson
Jack S. Richards
Peter M. Siba
Freya J. I. Fowkes
Eizo Takashima
Takafumi Tsuboi
Ivo Mueller
James G. Beeson
Targets of complement-fixing antibodies in protective immunity against malaria in children
description Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.
format article
author Linda Reiling
Michelle J. Boyle
Michael T. White
Danny W. Wilson
Gaoqian Feng
Rupert Weaver
D. Herbert Opi
Kristina E. M. Persson
Jack S. Richards
Peter M. Siba
Freya J. I. Fowkes
Eizo Takashima
Takafumi Tsuboi
Ivo Mueller
James G. Beeson
author_facet Linda Reiling
Michelle J. Boyle
Michael T. White
Danny W. Wilson
Gaoqian Feng
Rupert Weaver
D. Herbert Opi
Kristina E. M. Persson
Jack S. Richards
Peter M. Siba
Freya J. I. Fowkes
Eizo Takashima
Takafumi Tsuboi
Ivo Mueller
James G. Beeson
author_sort Linda Reiling
title Targets of complement-fixing antibodies in protective immunity against malaria in children
title_short Targets of complement-fixing antibodies in protective immunity against malaria in children
title_full Targets of complement-fixing antibodies in protective immunity against malaria in children
title_fullStr Targets of complement-fixing antibodies in protective immunity against malaria in children
title_full_unstemmed Targets of complement-fixing antibodies in protective immunity against malaria in children
title_sort targets of complement-fixing antibodies in protective immunity against malaria in children
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/997676a5fefb4ce79727443868c02da7
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