Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection.

Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection.

Toxoplasma gondii infects humans and warm blooded animals causing devastating disease worldwide. It has long been a mystery as to why the peritoneal macrophages of rats are naturally resistant to T. gondii infection while those of mice are not. Here, we report that high expression levels and activit...

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Bibliographic Details
Main Authors: Zhi Li, Zhi-Jun Zhao, Xing-Quan Zhu, Qing-Shi Ren, Fang-Fang Nie, Jiang-Mei Gao, Xiao-Jie Gao, Ting-Bao Yang, Wen-Liang Zhou, Ji-Long Shen, Yong Wang, Fang-Li Lu, Xiao-Guang Chen, Geoff Hide, Francisco J Ayala, Zhao-Rong Lun
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/998e48b8cc674417a97f322ec944f001
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https://doaj.org/article/998e48b8cc674417a97f322ec944f001

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