A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs

A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs

The therapeutic application of small interfering RNA (siRNA) is challenging due to its non-specific targeting and delivery issues. Here, the authors report an endogenous micro-RNA guided and hybridisation chain reaction-promoted siRNA delivery system encapsulated in tumour-derived extracellular vesi...

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Autores principales: Xue Gong, Haizhou Wang, Ruomeng Li, Kaiyue Tan, Jie Wei, Jing Wang, Chen Hong, Jinhua Shang, Xiaoqing Liu, Jing Liu, Fuan Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/99f09402e8ee4a48bb32cbcf8f7b6811
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spelling oai:doaj.org-article:99f09402e8ee4a48bb32cbcf8f7b68112021-12-02T18:02:41ZA smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs10.1038/s41467-021-24191-92041-1723https://doaj.org/article/99f09402e8ee4a48bb32cbcf8f7b68112021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24191-9https://doaj.org/toc/2041-1723The therapeutic application of small interfering RNA (siRNA) is challenging due to its non-specific targeting and delivery issues. Here, the authors report an endogenous micro-RNA guided and hybridisation chain reaction-promoted siRNA delivery system encapsulated in tumour-derived extracellular vesicles, with cancer-specific activation, and achieve silencing of hypoxia-related genes.Xue GongHaizhou WangRuomeng LiKaiyue TanJie WeiJing WangChen HongJinhua ShangXiaoqing LiuJing LiuFuan WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xue Gong
Haizhou Wang
Ruomeng Li
Kaiyue Tan
Jie Wei
Jing Wang
Chen Hong
Jinhua Shang
Xiaoqing Liu
Jing Liu
Fuan Wang
A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs
description The therapeutic application of small interfering RNA (siRNA) is challenging due to its non-specific targeting and delivery issues. Here, the authors report an endogenous micro-RNA guided and hybridisation chain reaction-promoted siRNA delivery system encapsulated in tumour-derived extracellular vesicles, with cancer-specific activation, and achieve silencing of hypoxia-related genes.
format article
author Xue Gong
Haizhou Wang
Ruomeng Li
Kaiyue Tan
Jie Wei
Jing Wang
Chen Hong
Jinhua Shang
Xiaoqing Liu
Jing Liu
Fuan Wang
author_facet Xue Gong
Haizhou Wang
Ruomeng Li
Kaiyue Tan
Jie Wei
Jing Wang
Chen Hong
Jinhua Shang
Xiaoqing Liu
Jing Liu
Fuan Wang
author_sort Xue Gong
title A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs
title_short A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs
title_full A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs
title_fullStr A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs
title_full_unstemmed A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs
title_sort smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related sirnas
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/99f09402e8ee4a48bb32cbcf8f7b6811
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