miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy

miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy

Skeletal muscle dysfunction may contribute to the progression and severity of amyotrophic lateral sclerosis (ALS). In the present study, we characterized the skeletal muscle pathophysiology in an inducible transgenic mouse model (rNLS8) that develops a TAR-DNA binding protein (TDP-43) proteinopathy...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Stavroula Tsitkanou, Paul A. Della Gatta, Gavin Abbott, Marita A. Wallace, Angus Lindsay, Frederico Gerlinger-Romero, Adam K. Walker, Victoria C. Foletta, Aaron P. Russell
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
Amyotrophic lateral sclerosis
Motor neuron disease
rNLS8 mice
TDP-43
Skeletal muscle
miR-23a
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Acceso en línea:https://doaj.org/article/9a0c4acf9c344503aa2f38b7f930adf4
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/9a0c4acf9c344503aa2f38b7f930adf4

Ejemplares similares