miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy
Skeletal muscle dysfunction may contribute to the progression and severity of amyotrophic lateral sclerosis (ALS). In the present study, we characterized the skeletal muscle pathophysiology in an inducible transgenic mouse model (rNLS8) that develops a TAR-DNA binding protein (TDP-43) proteinopathy...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Elsevier
2022
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/9a0c4acf9c344503aa2f38b7f930adf4 |
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