miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy

Skeletal muscle dysfunction may contribute to the progression and severity of amyotrophic lateral sclerosis (ALS). In the present study, we characterized the skeletal muscle pathophysiology in an inducible transgenic mouse model (rNLS8) that develops a TAR-DNA binding protein (TDP-43) proteinopathy...

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Bibliographic Details
Main Authors:	Stavroula Tsitkanou, Paul A. Della Gatta, Gavin Abbott, Marita A. Wallace, Angus Lindsay, Frederico Gerlinger-Romero, Adam K. Walker, Victoria C. Foletta, Aaron P. Russell
Format:	article
Language:	EN
Published:	Elsevier 2022
Subjects:	Amyotrophic lateral sclerosis Motor neuron disease rNLS8 mice TDP-43 Skeletal muscle miR-23a Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Online Access:	https://doaj.org/article/9a0c4acf9c344503aa2f38b7f930adf4
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miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy

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