Combined VEGFR and MAPK pathway inhibition in angiosarcoma

Combined VEGFR and MAPK pathway inhibition in angiosarcoma

Abstract Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited. Sequencing reveals multiple mutations in angiogenesis pathways in angiosarcomas, particularly in v...

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Autores principales: Michael J. Wagner, Yasmin A. Lyons, Jean H. Siedel, Robert Dood, Archana S. Nagaraja, Monika Haemmerle, Lingegowda S. Mangala, Pritha Chanana, Alexander J. Lazar, Wei-Lien Wang, Vinod Ravi, Eric C. Holland, Anil K. Sood
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/9a1d84942d65405f96863bf38797df82
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https://doaj.org/article/9a1d84942d65405f96863bf38797df82

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