Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

Single microtubules (MTs) can move chromosomes, but it is unclear why kinetochores bind up to 20 MTs. Here, the authors decrease the number of kinetochore MTs with BAL27862 and see lagging chromosomes, suggesting that numerous kinetochore MTs provide force ensuring robust chromosomal segregation.

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Autores principales:	Damian Dudka, Anna Noatynska, Chris A. Smith, Nicolas Liaudet, Andrew D. McAinsh, Patrick Meraldi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a3a7d104da04b9aaaf96e0d29c5129d
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spelling	oai:doaj.org-article:9a3a7d104da04b9aaaf96e0d29c5129d2021-12-02T15:33:42ZComplete microtubule–kinetochore occupancy favours the segregation of merotelic attachments10.1038/s41467-018-04427-x2041-1723https://doaj.org/article/9a3a7d104da04b9aaaf96e0d29c5129d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04427-xhttps://doaj.org/toc/2041-1723Single microtubules (MTs) can move chromosomes, but it is unclear why kinetochores bind up to 20 MTs. Here, the authors decrease the number of kinetochore MTs with BAL27862 and see lagging chromosomes, suggesting that numerous kinetochore MTs provide force ensuring robust chromosomal segregation.Damian DudkaAnna NoatynskaChris A. SmithNicolas LiaudetAndrew D. McAinshPatrick MeraldiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Damian Dudka Anna Noatynska Chris A. Smith Nicolas Liaudet Andrew D. McAinsh Patrick Meraldi Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
description	Single microtubules (MTs) can move chromosomes, but it is unclear why kinetochores bind up to 20 MTs. Here, the authors decrease the number of kinetochore MTs with BAL27862 and see lagging chromosomes, suggesting that numerous kinetochore MTs provide force ensuring robust chromosomal segregation.
format	article
author	Damian Dudka Anna Noatynska Chris A. Smith Nicolas Liaudet Andrew D. McAinsh Patrick Meraldi
author_facet	Damian Dudka Anna Noatynska Chris A. Smith Nicolas Liaudet Andrew D. McAinsh Patrick Meraldi
author_sort	Damian Dudka
title	Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
title_short	Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
title_full	Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
title_fullStr	Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
title_full_unstemmed	Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
title_sort	complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9a3a7d104da04b9aaaf96e0d29c5129d
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Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

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