Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR and integration sites and provide further insight...

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Autores principales:	Alyssa Sheih, Valentin Voillet, Laïla-Aïcha Hanafi, Hannah A. DeBerg, Masanao Yajima, Reed Hawkins, Vivian Gersuk, Stanley R. Riddell, David G. Maloney, Martin E. Wohlfahrt, Dnyanada Pande, Mark R. Enstrom, Hans-Peter Kiem, Jennifer E. Adair, Raphaël Gottardo, Peter S. Linsley, Cameron J. Turtle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a5dfb14385d4c6ba59269c0303b6190
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spelling	oai:doaj.org-article:9a5dfb14385d4c6ba59269c0303b61902021-12-02T17:33:00ZClonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy10.1038/s41467-019-13880-12041-1723https://doaj.org/article/9a5dfb14385d4c6ba59269c0303b61902020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13880-1https://doaj.org/toc/2041-1723Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR and integration sites and provide further insights into the role of transcriptional states in clonal kinetics.Alyssa SheihValentin VoilletLaïla-Aïcha HanafiHannah A. DeBergMasanao YajimaReed HawkinsVivian GersukStanley R. RiddellDavid G. MaloneyMartin E. WohlfahrtDnyanada PandeMark R. EnstromHans-Peter KiemJennifer E. AdairRaphaël GottardoPeter S. LinsleyCameron J. TurtleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyssa Sheih Valentin Voillet Laïla-Aïcha Hanafi Hannah A. DeBerg Masanao Yajima Reed Hawkins Vivian Gersuk Stanley R. Riddell David G. Maloney Martin E. Wohlfahrt Dnyanada Pande Mark R. Enstrom Hans-Peter Kiem Jennifer E. Adair Raphaël Gottardo Peter S. Linsley Cameron J. Turtle Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
description	Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR and integration sites and provide further insights into the role of transcriptional states in clonal kinetics.
format	article
author	Alyssa Sheih Valentin Voillet Laïla-Aïcha Hanafi Hannah A. DeBerg Masanao Yajima Reed Hawkins Vivian Gersuk Stanley R. Riddell David G. Maloney Martin E. Wohlfahrt Dnyanada Pande Mark R. Enstrom Hans-Peter Kiem Jennifer E. Adair Raphaël Gottardo Peter S. Linsley Cameron J. Turtle
author_facet	Alyssa Sheih Valentin Voillet Laïla-Aïcha Hanafi Hannah A. DeBerg Masanao Yajima Reed Hawkins Vivian Gersuk Stanley R. Riddell David G. Maloney Martin E. Wohlfahrt Dnyanada Pande Mark R. Enstrom Hans-Peter Kiem Jennifer E. Adair Raphaël Gottardo Peter S. Linsley Cameron J. Turtle
author_sort	Alyssa Sheih
title	Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
title_short	Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
title_full	Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
title_fullStr	Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
title_full_unstemmed	Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
title_sort	clonal kinetics and single-cell transcriptional profiling of car-t cells in patients undergoing cd19 car-t immunotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9a5dfb14385d4c6ba59269c0303b6190
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Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

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