Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.
Kohlschütter-Tönz syndrome (KTS) manifests as neurological dysfunctions, including early-onset seizures. Mutations in the citrate transporter SLC13A5 are associated with KTS, yet their underlying mechanisms remain elusive. Here, we report that a Drosophila SLC13A5 homolog, I'm not dead yet (Ind...
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Main Authors: | , , , |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2021
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Subjects: | |
Online Access: | https://doaj.org/article/9a656d4d0f794afb8c5a3b195cb8b474 |
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