The Effect of tRNA<sup>[Ser]Sec</sup> Isopentenylation on Selenoprotein Expression

The Effect of tRNA<sup>[Ser]Sec</sup> Isopentenylation on Selenoprotein Expression

Transfer RNA<sup>[Ser]Sec</sup> carries multiple post-transcriptional modifications. The A37G mutation in tRNA<sup>[Ser]Sec</sup> abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R323Q...

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Autores principales: Noelia Fradejas-Villar, Simon Bohleber, Wenchao Zhao, Uschi Reuter, Annika Kotter, Mark Helm, Rainer Knoll, Robert McFarland, Robert W. Taylor, Yufeng Mo, Kenjyo Miyauchi, Yuriko Sakaguchi, Tsutomu Suzuki, Ulrich Schweizer
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>Trit1</i>
isopentenylation
tRNA<sup>[Ser]Sec</sup>
selenoproteins
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/9a8205bba91f4fc3874f11f8544724c3
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https://doaj.org/article/9a8205bba91f4fc3874f11f8544724c3

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