The Effect of tRNA<sup>[Ser]Sec</sup> Isopentenylation on Selenoprotein Expression
Transfer RNA<sup>[Ser]Sec</sup> carries multiple post-transcriptional modifications. The A37G mutation in tRNA<sup>[Ser]Sec</sup> abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R323Q...
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Main Authors: | , , , , , , , , , , , , , |
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Format: | article |
Language: | EN |
Published: |
MDPI AG
2021
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Subjects: | |
Online Access: | https://doaj.org/article/9a8205bba91f4fc3874f11f8544724c3 |
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