Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.

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Détails bibliographiques
Auteurs principaux: Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G. Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, Zuoren Yu
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/9aa0306ca7c642ed86793ac064932e62
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Internet

https://doaj.org/article/9aa0306ca7c642ed86793ac064932e62

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