Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/9aa0306ca7c642ed86793ac064932e62 |
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oai:doaj.org-article:9aa0306ca7c642ed86793ac064932e622021-12-02T14:40:32ZSmall RNA zippers lock miRNA molecules and block miRNA function in mammalian cells10.1038/ncomms139642041-1723https://doaj.org/article/9aa0306ca7c642ed86793ac064932e622017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13964https://doaj.org/toc/2041-1723MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.Lingyu MengCuicui LiuJinhui LüQian ZhaoShengqiong DengGuangxue WangJing QiaoChuyi ZhangLixiao ZhenYing LuWenshu LiYuzhen ZhangRichard G. PestellHuiming FanYi-Han ChenZhongmin LiuZuoren YuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G. Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells |
| description |
MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes. |
| format |
article |
| author |
Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G. Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu |
| author_facet |
Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G. Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu |
| author_sort |
Lingyu Meng |
| title |
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells |
| title_short |
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells |
| title_full |
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells |
| title_fullStr |
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells |
| title_full_unstemmed |
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells |
| title_sort |
small rna zippers lock mirna molecules and block mirna function in mammalian cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/9aa0306ca7c642ed86793ac064932e62 |
| work_keys_str_mv |
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