Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-impose...

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Autores principales: Janett Göhring, Florian Kellner, Lukas Schrangl, René Platzer, Enrico Klotzsch, Hannes Stockinger, Johannes B. Huppa, Gerhard J. Schütz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9aaa195dbacc438b8940b42f235fb0e2
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