Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-impose...

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Autores principales:	Janett Göhring, Florian Kellner, Lukas Schrangl, René Platzer, Enrico Klotzsch, Hannes Stockinger, Johannes B. Huppa, Gerhard J. Schütz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9aaa195dbacc438b8940b42f235fb0e2
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spelling	oai:doaj.org-article:9aaa195dbacc438b8940b42f235fb0e22021-12-02T14:29:13ZTemporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements10.1038/s41467-021-22775-z2041-1723https://doaj.org/article/9aaa195dbacc438b8940b42f235fb0e22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22775-zhttps://doaj.org/toc/2041-1723Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level.Janett GöhringFlorian KellnerLukas SchranglRené PlatzerEnrico KlotzschHannes StockingerJohannes B. HuppaGerhard J. SchützNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janett Göhring Florian Kellner Lukas Schrangl René Platzer Enrico Klotzsch Hannes Stockinger Johannes B. Huppa Gerhard J. Schütz Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
description	Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level.
format	article
author	Janett Göhring Florian Kellner Lukas Schrangl René Platzer Enrico Klotzsch Hannes Stockinger Johannes B. Huppa Gerhard J. Schütz
author_facet	Janett Göhring Florian Kellner Lukas Schrangl René Platzer Enrico Klotzsch Hannes Stockinger Johannes B. Huppa Gerhard J. Schütz
author_sort	Janett Göhring
title	Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
title_short	Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
title_full	Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
title_fullStr	Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
title_full_unstemmed	Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
title_sort	temporal analysis of t-cell receptor-imposed forces via quantitative single molecule fret measurements
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9aaa195dbacc438b8940b42f235fb0e2
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Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements

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