TLR2 controls intestinal carcinogen detoxication by CYP1A1.

Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcri...

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Auteurs principaux: Khoa Nguyen Do, Lisbeth Nielsen Fink, Thomas Elbenhardt Jensen, Laurent Gautier, Alexandr Parlesak
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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R
Q
Accès en ligne:https://doaj.org/article/9af26b7866974fa6be10e0dc5d785b51
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