Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with...

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Autores principales: Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou K. S. Camara, Wai-Meng Kwok, Emad Tajkhorshid
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc
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