Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with...

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Autores principales:	Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou K. S. Camara, Wai-Meng Kwok, Emad Tajkhorshid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc
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spelling	oai:doaj.org-article:9b0ee7be8cd74a3aaff79ae00681eddc2021-12-02T18:25:01ZStructural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II10.1038/s42003-021-02205-y2399-3642https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02205-yhttps://doaj.org/toc/2399-3642Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic surface of OMM to form a binary complex.Nandan HaloiPo-Chao WenQunli ChengMeiying YangGayathri NatarajanAmadou K. S. CamaraWai-Meng KwokEmad TajkhorshidNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nandan Haloi Po-Chao Wen Qunli Cheng Meiying Yang Gayathri Natarajan Amadou K. S. Camara Wai-Meng Kwok Emad Tajkhorshid Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
description	Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic surface of OMM to form a binary complex.
format	article
author	Nandan Haloi Po-Chao Wen Qunli Cheng Meiying Yang Gayathri Natarajan Amadou K. S. Camara Wai-Meng Kwok Emad Tajkhorshid
author_facet	Nandan Haloi Po-Chao Wen Qunli Cheng Meiying Yang Gayathri Natarajan Amadou K. S. Camara Wai-Meng Kwok Emad Tajkhorshid
author_sort	Nandan Haloi
title	Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
title_short	Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
title_full	Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
title_fullStr	Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
title_full_unstemmed	Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
title_sort	structural basis of complex formation between mitochondrial anion channel vdac1 and hexokinase-ii
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc
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Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

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