Inducible knockout of Clec16a in mice results in sensory neurodegeneration

Inducible knockout of Clec16a in mice results in sensory neurodegeneration

Abstract CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout, Clec16a ΔUBC mice, to investigate the loss of function of CLEC16A. The mice...

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Main Authors: Heather S. Hain, Rahul Pandey, Marina Bakay, Bryan P. Strenkowski, Danielle Harrington, Micah Romer, William W. Motley, Jian Li, Eunjoo Lancaster, Lindsay Roth, Judith B. Grinspan, Steven S. Scherer, Hakon Hakonarson
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/9b104a7aa9a7427988082d3423e2cc80
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https://doaj.org/article/9b104a7aa9a7427988082d3423e2cc80

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