Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors

Abstract A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection inv...

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Autores principales:	Fengju Chen, Yiqun Zhang, Richard Sucgang, Sasirekha Ramani, David Corry, Farrah Kheradmand, Chad J. Creighton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b32e15347954632ac38e333b12d3c55
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spelling	oai:doaj.org-article:9b32e15347954632ac38e333b12d3c552021-12-02T13:57:37ZMeta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors10.1038/s41598-021-82221-42045-2322https://doaj.org/article/9b32e15347954632ac38e333b12d3c552021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82221-4https://doaj.org/toc/2045-2322Abstract A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hundreds of genes common across lung adenocarcinoma cell lines (A549, Calu-3) and normal human bronchial epithelial cells (NHBE), with additional signatures being specific to one or both adenocarcinoma lines. Cross-examining eight transcriptomic databases, we found that host transcriptional responses of lung adenocarcinoma cells to SARS-CoV-2 infection shared broad similarities with host responses to multiple viruses across different model systems and patient samples. Furthermore, these SARS-CoV-2 transcriptional signatures were manifested within specific subsets of human cancer, involving ~ 20% of cases across a wide range of histopathological types. These cancer subsets show immune cell infiltration and inflammation and involve pathways linked to the SARS-CoV-2 response, such as immune checkpoint, IL-6, type II interferon signaling, and NF-κB. The cell line data represented immune responses activated specifically within the cancer cells of the tumor. Common genes and pathways implicated as part of the viral host response point to therapeutic strategies that may apply to both SARS-CoV-2 and cancer.Fengju ChenYiqun ZhangRichard SucgangSasirekha RamaniDavid CorryFarrah KheradmandChad J. CreightonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fengju Chen Yiqun Zhang Richard Sucgang Sasirekha Ramani David Corry Farrah Kheradmand Chad J. Creighton Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
description	Abstract A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hundreds of genes common across lung adenocarcinoma cell lines (A549, Calu-3) and normal human bronchial epithelial cells (NHBE), with additional signatures being specific to one or both adenocarcinoma lines. Cross-examining eight transcriptomic databases, we found that host transcriptional responses of lung adenocarcinoma cells to SARS-CoV-2 infection shared broad similarities with host responses to multiple viruses across different model systems and patient samples. Furthermore, these SARS-CoV-2 transcriptional signatures were manifested within specific subsets of human cancer, involving ~ 20% of cases across a wide range of histopathological types. These cancer subsets show immune cell infiltration and inflammation and involve pathways linked to the SARS-CoV-2 response, such as immune checkpoint, IL-6, type II interferon signaling, and NF-κB. The cell line data represented immune responses activated specifically within the cancer cells of the tumor. Common genes and pathways implicated as part of the viral host response point to therapeutic strategies that may apply to both SARS-CoV-2 and cancer.
format	article
author	Fengju Chen Yiqun Zhang Richard Sucgang Sasirekha Ramani David Corry Farrah Kheradmand Chad J. Creighton
author_facet	Fengju Chen Yiqun Zhang Richard Sucgang Sasirekha Ramani David Corry Farrah Kheradmand Chad J. Creighton
author_sort	Fengju Chen
title	Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
title_short	Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
title_full	Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
title_fullStr	Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
title_full_unstemmed	Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
title_sort	meta-analysis of host transcriptional responses to sars-cov-2 infection reveals their manifestation in human tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b32e15347954632ac38e333b12d3c55
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Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors

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