Accurate detection of m6A RNA modifications in native RNA sequences

We currently lack generic methods to map RNA modifications across the entire transcriptome. Here, the authors demonstrate that m6A RNA modifications can be detected with high accuracy using nanopore direct RNA sequencing.

Guardado en:

Detalles Bibliográficos
Autores principales:	Huanle Liu, Oguzhan Begik, Morghan C. Lucas, Jose Miguel Ramirez, Christopher E. Mason, David Wiener, Schraga Schwartz, John S. Mattick, Martin A. Smith, Eva Maria Novoa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b36004b41f44913a89a8cca26a8ff72
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9b36004b41f44913a89a8cca26a8ff72
record_format	dspace
spelling	oai:doaj.org-article:9b36004b41f44913a89a8cca26a8ff722021-12-02T17:01:53ZAccurate detection of m6A RNA modifications in native RNA sequences10.1038/s41467-019-11713-92041-1723https://doaj.org/article/9b36004b41f44913a89a8cca26a8ff722019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11713-9https://doaj.org/toc/2041-1723We currently lack generic methods to map RNA modifications across the entire transcriptome. Here, the authors demonstrate that m6A RNA modifications can be detected with high accuracy using nanopore direct RNA sequencing.Huanle LiuOguzhan BegikMorghan C. LucasJose Miguel RamirezChristopher E. MasonDavid WienerSchraga SchwartzJohn S. MattickMartin A. SmithEva Maria NovoaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huanle Liu Oguzhan Begik Morghan C. Lucas Jose Miguel Ramirez Christopher E. Mason David Wiener Schraga Schwartz John S. Mattick Martin A. Smith Eva Maria Novoa Accurate detection of m6A RNA modifications in native RNA sequences
description	We currently lack generic methods to map RNA modifications across the entire transcriptome. Here, the authors demonstrate that m6A RNA modifications can be detected with high accuracy using nanopore direct RNA sequencing.
format	article
author	Huanle Liu Oguzhan Begik Morghan C. Lucas Jose Miguel Ramirez Christopher E. Mason David Wiener Schraga Schwartz John S. Mattick Martin A. Smith Eva Maria Novoa
author_facet	Huanle Liu Oguzhan Begik Morghan C. Lucas Jose Miguel Ramirez Christopher E. Mason David Wiener Schraga Schwartz John S. Mattick Martin A. Smith Eva Maria Novoa
author_sort	Huanle Liu
title	Accurate detection of m6A RNA modifications in native RNA sequences
title_short	Accurate detection of m6A RNA modifications in native RNA sequences
title_full	Accurate detection of m6A RNA modifications in native RNA sequences
title_fullStr	Accurate detection of m6A RNA modifications in native RNA sequences
title_full_unstemmed	Accurate detection of m6A RNA modifications in native RNA sequences
title_sort	accurate detection of m6a rna modifications in native rna sequences
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9b36004b41f44913a89a8cca26a8ff72
work_keys_str_mv	AT huanleliu accuratedetectionofm6arnamodificationsinnativernasequences AT oguzhanbegik accuratedetectionofm6arnamodificationsinnativernasequences AT morghanclucas accuratedetectionofm6arnamodificationsinnativernasequences AT josemiguelramirez accuratedetectionofm6arnamodificationsinnativernasequences AT christopheremason accuratedetectionofm6arnamodificationsinnativernasequences AT davidwiener accuratedetectionofm6arnamodificationsinnativernasequences AT schragaschwartz accuratedetectionofm6arnamodificationsinnativernasequences AT johnsmattick accuratedetectionofm6arnamodificationsinnativernasequences AT martinasmith accuratedetectionofm6arnamodificationsinnativernasequences AT evamarianovoa accuratedetectionofm6arnamodificationsinnativernasequences
_version_	1718382042042859520

Accurate detection of m6A RNA modifications in native RNA sequences

Ejemplares similares