Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with cognitive resilience.
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Nature Portfolio
2019
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oai:doaj.org-article:9b58a9346e234b21a9e82096eeb3d5082021-12-02T15:35:47ZLarge-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age10.1038/s41467-019-09613-z2041-1723https://doaj.org/article/9b58a9346e234b21a9e82096eeb3d5082019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09613-zhttps://doaj.org/toc/2041-1723Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with cognitive resilience.Aliza P. WingoEric B. DammerMichael S. BreenBenjamin A. LogsdonDuc M. DuongJuan C. TroncoscoMadhav ThambisettyThomas G. BeachGeidy E. SerranoEric M. ReimanRichard J. CaselliJames J. LahNicholas T. SeyfriedAllan I. LeveyThomas S. WingoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Aliza P. Wingo Eric B. Dammer Michael S. Breen Benjamin A. Logsdon Duc M. Duong Juan C. Troncosco Madhav Thambisetty Thomas G. Beach Geidy E. Serrano Eric M. Reiman Richard J. Caselli James J. Lah Nicholas T. Seyfried Allan I. Levey Thomas S. Wingo Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| description |
Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with cognitive resilience. |
| format |
article |
| author |
Aliza P. Wingo Eric B. Dammer Michael S. Breen Benjamin A. Logsdon Duc M. Duong Juan C. Troncosco Madhav Thambisetty Thomas G. Beach Geidy E. Serrano Eric M. Reiman Richard J. Caselli James J. Lah Nicholas T. Seyfried Allan I. Levey Thomas S. Wingo |
| author_facet |
Aliza P. Wingo Eric B. Dammer Michael S. Breen Benjamin A. Logsdon Duc M. Duong Juan C. Troncosco Madhav Thambisetty Thomas G. Beach Geidy E. Serrano Eric M. Reiman Richard J. Caselli James J. Lah Nicholas T. Seyfried Allan I. Levey Thomas S. Wingo |
| author_sort |
Aliza P. Wingo |
| title |
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| title_short |
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| title_full |
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| title_fullStr |
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| title_full_unstemmed |
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| title_sort |
large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/9b58a9346e234b21a9e82096eeb3d508 |
| work_keys_str_mv |
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