Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci.

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Detalles Bibliográficos
Autores principales: Helen E. Speedy, Renée Beekman, Vicente Chapaprieta, Giulia Orlando, Philip J. Law, David Martín-García, Jesús Gutiérrez-Abril, Daniel Catovsky, Sílvia Beà, Guillem Clot, Montserrat Puiggròs, David Torrents, Xose S. Puente, James M. Allan, Carlos López-Otín, Elias Campo, Richard S. Houlston, José I. Martín-Subero
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/9b5b6327af3c440e9c59830da14206ad
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Internet

https://doaj.org/article/9b5b6327af3c440e9c59830da14206ad

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