Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics
The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci.
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Nature Portfolio
2019
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oai:doaj.org-article:9b5b6327af3c440e9c59830da14206ad2021-12-02T15:36:03ZInsight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics10.1038/s41467-019-11582-22041-1723https://doaj.org/article/9b5b6327af3c440e9c59830da14206ad2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11582-2https://doaj.org/toc/2041-1723The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci.Helen E. SpeedyRenée BeekmanVicente ChapaprietaGiulia OrlandoPhilip J. LawDavid Martín-GarcíaJesús Gutiérrez-AbrilDaniel CatovskySílvia BeàGuillem ClotMontserrat PuiggròsDavid TorrentsXose S. PuenteJames M. AllanCarlos López-OtínElias CampoRichard S. HoulstonJosé I. Martín-SuberoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
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| topic |
Science Q |
| spellingShingle |
Science Q Helen E. Speedy Renée Beekman Vicente Chapaprieta Giulia Orlando Philip J. Law David Martín-García Jesús Gutiérrez-Abril Daniel Catovsky Sílvia Beà Guillem Clot Montserrat Puiggròs David Torrents Xose S. Puente James M. Allan Carlos López-Otín Elias Campo Richard S. Houlston José I. Martín-Subero Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| description |
The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci. |
| format |
article |
| author |
Helen E. Speedy Renée Beekman Vicente Chapaprieta Giulia Orlando Philip J. Law David Martín-García Jesús Gutiérrez-Abril Daniel Catovsky Sílvia Beà Guillem Clot Montserrat Puiggròs David Torrents Xose S. Puente James M. Allan Carlos López-Otín Elias Campo Richard S. Houlston José I. Martín-Subero |
| author_facet |
Helen E. Speedy Renée Beekman Vicente Chapaprieta Giulia Orlando Philip J. Law David Martín-García Jesús Gutiérrez-Abril Daniel Catovsky Sílvia Beà Guillem Clot Montserrat Puiggròs David Torrents Xose S. Puente James M. Allan Carlos López-Otín Elias Campo Richard S. Houlston José I. Martín-Subero |
| author_sort |
Helen E. Speedy |
| title |
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| title_short |
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| title_full |
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| title_fullStr |
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| title_full_unstemmed |
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| title_sort |
insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/9b5b6327af3c440e9c59830da14206ad |
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| _version_ |
1718386370043445248 |