Antibody cross-reactivity accounts for widespread appearance of m1A in 5’UTRs

N 1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5. Further, they show that the previously reported enrichment o...

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Bibliographic Details
Main Authors: Anya V. Grozhik, Anthony O. Olarerin-George, Miriam Sindelar, Xing Li, Steven S. Gross, Samie R. Jaffrey
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/9b5c924dc48f490aafd659539f03fc90
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