A five-residue motif for the design of domain swapping in proteins

Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and structurally unrelated host proteins, providing...

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Autores principales: Neha Nandwani, Parag Surana, Hitendra Negi, Nahren M. Mascarenhas, Jayant B. Udgaonkar, Ranabir Das, Shachi Gosavi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9b6bdc87e3ab4b35a3fc024b6c07e914
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